#1 TRIPHALA
Triphala or “three fruits” is a combination of the myrobalan family of fruits commonly eaten in Asia.   Triphala is a traditional remedy for deep digestive cleansing and balancing and one of the most important traditional herbal formulas for efficient digestive functioning.
Triphala helps to deep cleanse on the micro-level including the villi hairs of the intestines.  Clean intestines are necessary for proper nutrient assimilation and consequent good healthy weight management.  Also, a clean digestive system allows for better digestion of foods and absorption of foods and, therefore, healthier satisfaction with less bulky or nutrient deficient meal portions.
#2 MORMODICA CHIRANTIA
Mormodica chirantia or Bitter Melon is a traditional food used in the balancing of blood sugar and has been used historically for pre-diabetic conditions or advanced blood sugar imbalance conditions.
#3 SHILAJIT
Shilajit is known historically as the “Destroyer of Weakness” the herbal ingredient, Shilajit, contains over sixty trace minerals and is used for anti-fatigue purposes in traditional medicine.  Shilajit has naturally occurring Fulvic Acid and Humic Acid to help support general strength and vital health. Shilajit is often used traditionally for blood sugar balancing which may help to prevent hunger issues. In traditional medicine Shilajit is considered a panacea herbal remedy since it has so many positive benefits for supporting good health, strengthening and general vitality.
#4 AMYLASE
Amylase is an important digestive enzyme that helps to breakdown carbohydrates in the digestive system.  Good digestion is a fundamental key to healthy weight management.
#5 BERBERIS ARISTATA
Berberis aristata herb contains naturally occurring berberine which has been linked to the control of blood sugar balancing and anti-diabetic actions
#6 CARDAMOM
Cardamom is a traditional spice used historically for good digestion, water retention conditions and, thereby, lowering of blood pressure.  Good digestion and elimination of excess water retention is important for heathy weight management.
#7 PROTEASE
Protease is a natural enzyme as found in the digestive system that is used by the body to break down protein containing foods.   Lack of protease enzymes can lead to poor digestion, weight gain and accumulation of excessive waste for elimination as a body burden.
#8 GUGGUL
Guggul OR Commiphora mukul is a traditional herbal remedy for the maintenance of healthy weight management, activation of thyroid functions and a balance of metabolism.
#9 BOERHAAVIA DIFFUSA
Boerhaavia diffusa or Purnarnav is a traditional herb used for healthy digestion and balancing of the digestive system and is also acts as a mild diuretic.
#10 TRIBULUS TERRESTRIS
Tribulus terrestris is a traditional herb used as a mild diuretic.
#11 TURMERIC
Turmeric or Cucuma longa, a natural traditional culinary spice, can help to reduce edema and inflammation associated with over-weight conditions.   Turmeric is naturally anti-inflammatory.

SCIENCE

WEIGHTLESS™ FORMULA (The Science)

Losing Weight Naturally with NO STIMULANTS

WEIGHTLESS™  weight management Formula Ingredients, as below, based upon a non-stimulating approach to weight loss including cleansing for better nutrient absorption, water weight control and the balancing of blood sugars to reduce hunger:

TRIPHALA

Triphala or “three fruits” is a combination of the myrobalan family of fruits commonly eaten in Asia.   Triphala is a traditional remedy for deep digestive cleansing and balancing and one of the most important traditional herbal formulas for efficient digestive functioning. 

Triphala helps to deep cleanse on the micro-level including the villi hairs of the intestines.  Clean intestines are necessary for proper nutrient assimilation and consequent good healthy weight management.  Also, a clean digestive system allows for better digestion of foods and absorption of foods and, therefore, healthier satisfaction with less bulky or nutrient deficient meal portions.

REFERENCES:

• PULOK K. MUKHERJEE, SUJAY RAI, SAUVIK BHATTACHARYYA, PRATIP KUMAR DEBNATH, TUHIN KANTI BISWAS, UTPALENDU JANA, SRIKANTA PANDIT, BISHNU PADA SAHA, PRADIP K. PAUL, Clinical Study of ‘Triphala’ – A Well Known Phytomedicine from India IRANIAN JOURNAL OF PHARMACOLOGY & THERAPEUTICS Copyright © 2006 by Razi Institute for Drug Research (RIDR) IJPT 5:51-54, 2006.
• Scientific validation of the ethnomedicinal properties of the Ayurvedic drug Triphala: A review.  Chinese Journal of Integrative Medicine  December 2012, Volume 18, Issue 12, pp 946–954.
• Pratya Phetkate, Tanawan Kummalue, Yaowalak U-pratya, and Somboon Kietinun.  Significant Increase in Cytotoxic T Lymphocytes and Natural Killer Cells by Triphala: A Clinical Phase I Study.  Faculty of Medicine, Thammasat University, Pathumthani 12121, Thailand.

MORMODICA CHIRANTIA

Mormodica chirantia or Bitter Melon is a traditional food used in the balancing of blood sugar and has been used historically for pre-diabetic conditions or advanced blood sugar imbalance conditions.   

Studies have shown that Bitter Melon may help reduce fat and by balancing blood sugar levels, stabilizing insulin and helping to prevent over-eating.  Bitter melon contains enzymes that break down fat into free fatty acids.  

REFERENCES:

• Pratibha V NerurkarEmail author, Yun-Kung Lee and Vivek R Nerurkar.  J Lipids  Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes.  BMC Complementary and Alternative Medicine The official journal of the International Society for Complementary Medicine Research (ISCMR)2010  
• Baby Joseph and D Jini.  Asian Pac J Trop Dis. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency.  2013 Apr; 3(2): 93–102.

SHILAJIT

Shilajit is known historically as the “Destroyer of Weakness” the herbal ingredient, Shilajit, contains over sixty trace minerals and is used for anti-fatigue purposes in traditional medicine.  Shilajit has naturally occurring Fulvic Acid and Humic Acid to help support general strength and vital health.

Shilajit is often used traditionally for blood sugar balancing which may help to prevent hunger issues.     

In traditional medicine Shilajit is considered a panacea herbal remedy since it has so many positive benefits for supporting good health, strengthening and general vitality.

REFERENCES:

• Ghosal S, Reddy JP, Lal VK Shilajit I: chemical constituents . J Pharm Sci. (1976)
• Acharya SB, et al Pharmacological actions of Shilajit . Indian J Exp Biol. (1988)
• Agarwal SP, et al Shilajit: a review . Phytother Res. (2007)
• Meena H, et al Shilajit: A panacea for high-altitude problems . Int J Ayurveda Res. (2010)The need for formulation of shilajit by its isolated active constituents
• Bucci LR Selected herbals and human exercise performance . Am J Clin Nutr. (2000)
• Biswas TK, et al Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia . Andrologia. (2010)

AMYLASE

Amylase is an important digestive enzyme that helps to breakdown carbohydrates in the digestive system.  Good digestion is a fundamental key to healthy weight management.  

BERBERIS ARISTATA

Berberis aristata herb contains naturally occurring berberine which has been linked to the control of blood sugar balancing and anti-diabetic actions

In two studies to measure weight it was noted that obese people (one with metabolic syndrome, the other being ‘otherwise healthy’) who consumed berberine had weight loss of roughly 6-13% over just 3 months. Diet was not recorded during this time, but berberine seems to have anti-obese effects.

REFERENCES:

• http://www.ncbi.nlm.nih.gov/pubmed/23118793
• http://www.ncbi.nlm.nih.gov/pubmed/22739410
• http://www.ncbi.nlm.nih.gov/pubmed/22474499
• http://www.ncbi.nlm.nih.gov/pubmed/18355829
• http://www.ncbi.nlm.nih.gov/pubmed/19687008

CARDAMOM

Cardamom is a traditional spice used historically for good digestion, water retention conditions and, thereby, lowering of blood pressure.  Good digestion and elimination of excess water retention is important for heathy weight management.

REFERENCES:

• Yuang YB, Fang JY, Hung CH, et al. Cyclic monoterpene extract from cardamom oil as a skin permeation enhancer for indomethacin: Jafri MA, Farah, Javed K, et al. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Biol Pharm Bull. 1999 Jun;22(6):642-6.
• Jamal A, Javed K, Aslam M, et al. Gastroprotective effect of cardamom, Indian J Exp Biol. 1999 Mar;37(3):238-42.
• Kumar S. Panmasala chewing induces deterioration in oral health and its implications in carcinogenesis. Toxicol Mech Methods 2008;18(9):665-677. 
• Martins AP, Salgueiro L, Goncalves MJ, et al. Essential oil composition and antimicrobial activity of three Zingiberaceae from S.Tome e Principe. Planta Med 2001;67(6):580-584.
• Sapra B, Gupta S, Tiwary AK. Role of volatile oil pretreatment and skin cholesterol on permeation of ion-paired diclofenac sodium. Indian J Exp Biol 2000;38(9):895-900. 
  

PROTEASE

Protease is a natural enzyme as found in the digestive system that is used by the body to break down protein containing foods.   Lack of protease enzymes can lead to poor digestion, weight gain and accumulation of excessive waste for elimination as a body burden.

REFERENCES:

• Buck JE, Phillips N. Trial of Chymoral in professional footballers. Br J Clin Pract. 1970 Sep;24(9):375-7.
• Craig RP. The quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. Injury. 1975 May;6(4):313-6.
• Fisher JD, Weeks RL, Curry WM, Hrinda ME, Rosen LL. Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man. J Med. 1974;5(5):258-73.
• Lie KK, Larsen RD, Posch JL. Therapeutic value of oral proteolytic enzymes following hand surgery. Arch Surg. 1969 Jan;98(1):103-4.
• Hale LP, Chichlowski M, Trinh CT, Greer PK. Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. doi: 10.1002/ibd.21320.
• Gomes FS, Spínola Cde V, Ribeiro HA, Lopes MT, Cassali GD, Salas CE. Wound-healing activity of a proteolytic fraction from Carica candamarcensis on experimentally induced burn. Burns. 2010 Mar;36(2):277-83. doi: 10.1016/j.burns.2009.04.007.

GUGGUL

Guggul OR Commiphora mukul is a traditional herbal remedy for the maintenance of healthy weight management, activation of thyroid functions and a balance of metabolism.   

REFERENCES:

1. Anurekha, J., & Gupta, V. B. (2006). Chemistry and pharmacological profile of guggul: A review. Indian Journal of Traditional Knowledge, 5(4), 478-483.
2. Singh, B. B., Mishra, L. C., Aquilina, N., & Kohlbeck, F. (2001). Usefulness of guggul (Commiphora mukul) for osteoarthritis of the knee: An experimental case study. Alternative therapies in health and medicine, 7(2), 120-112. 

BOERHAAVIA DIFFUSA

Boerhaavia diffusa or Punarnav is a traditional herb used for healthy digestion and balancing of the digestive system and also acts as a mild diuretic.  

REFERENCES:

• Pari, L., and M. Amarnath Satheesh. “Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes.” Journal of ethnopharmacology 91.1 (2004): 109-113.
• Satheesh, M. Amarnath, and L. Pari. “Antioxidant effect of Boerhavia diffusa L. in tissues of alloxan induced diabetic rats.” Indian J Exp Biol 42.10 (2004): 989-92.
• Singh, Prem Kumar, Darshee Baxi, and Ankita Doshi. “Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats.” Journal of Complementary and Integrative Medicine 8.1 (2011).
•  Sreeja, Sreekumar, and Sreeharshan Sreeja. “An in vitro study on antiproliferative and antiestrogenic effects of Boerhaavia diffusa L. extracts.” Journal of ethnopharmacology 126.2 (2009): 221-225.
• Singh, S. K. P., B. L. Pandey, and R. G. Singh. “Recent approach in clinical and experimental evaluation of diuretic action of Punarnava.” (1992).
• Mudgal V. “Studies on medicinal properties of Convolvulus pluricaulis and Boerhaavia diffusa.” Planta Med. (1975)
• Nalamolu, Rao K., Krishna M. Boini, and Srinivas Nammi. “Effect of chronic administration of Boerhaavia diffusa Linn. leaf extract on experimental diabetes in rats.” Tropical Journal of Pharmaceutical Research 3.1 (2007): 305-309.
• Pareta, Surendra K., et al. “Aqueous extract of Boerhaavia diffusa root ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney.” Pharmaceutical biology 49.12 (2011): 1224-1233.
• Yasir, Fauzia, and Muhammad A. Waqar. “Effect of indigenous plant extracts on calcium oxalate crystallization having a role in urolithiasis.” Urological research 39.5 (2011): 345-350.
• Gholap, S., and A. Kar. “Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration.” Die Pharmazie-An International Journal of Pharmaceutical Sciences 59.11 (2004): 876-878.
• Rawat, A. K. S., et al. “Hepatoprotective activity of Boerhaavia diffusa L. roots—a popular Indian ethnomedicine.” Journal of ethnopharmacology 56.1 (1997): 61-66.

TRIBULUS TERRESTRIS

Tribulus terrestris is a traditional herb used as a mild diuretic.

REFERENCES:

• Viktorov IV, Kaloyanov AL, Lilov L, et al. Clinical investigation on Tribestan in males with disorders in the sexual function. Med-Biol Inf. 1982.
• Milanov, S. et al., Tribestan effect on the concentration of some hormones in serum of healthy subjects, 1983.
• Jayaram S, et al. Tribulus. Indian Drugs 1993;30(10):498-500.  Quoted in Natural Plants Effective in Treatment of Sexual Dysfunction: A Review, NK Saini, M Singhai B Srivastava and S Sharma. 
• 406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris] Wang B; Ma L; Liu T Research Unit of Cardiovascular Disease, Jilin Medical College. Chung Hsi I Chieh Ho Tsa Chih Feb 1990, 10 (2) p87-7, 68.

TURMERIC 

ic or Cucuma longa, a natural traditional culinary spice, can help to reduce edema and inflammation associated with overweight conditions.   Turmeric is naturally anti-inflammatory.

In a study, it has been shown to modulate the metabolic activities in the white adipose (fat) tissues that prevent angiogenesis. This in turn results in decreased fat accumulation.

Curcumin has also been found to decrease the size of adipose tissues, i.e. lower fat accumulation in overweight patients. The body measurements of these patients showed significant reduction of fat.

Moreover, it has been observed that turmeric along with sulphur can prevent fat deposition and improve the lipid profile of blood and liver in over-weight individuals.

Turmeric blocks fat cells from forming and expanding:   

In a study at Tufts University called “Curcumin (main ingredient in Turmeric) Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice” in 2009

They found the following:

“We investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3T3-L1 adipocyte in cell culture systems and on body weight gain and adiposity in mice fed a high-fat diet (22%) supplemented with 500 mg curcumin/kg diet for 12 wk.”   Findings: “The curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain. Our findings suggest that dietary curcumin, present in turmeric, may have a potential benefit in preventing obesity.”

REFERENCES:

• Bisset NG. Max Wichtl’s herbal drugs & phytochemicals. Boca Raton, FL: CRC Press 1994. 
• Bruneton J. Pharmacology, phytochemistry, medicinal plants. Paris: Lavoisier 1995. 
• Osawa T, Sugiyama Y, Inayoshi M, Kawakishi S. Antioxidative activity of tetrahydrocurcuminoids. Biosci Biotechnol Biochem 1995; 59(9): 1609-1612. 
• Sreejayan N, Rao MNA, Priyadarsini KI, Devasagayam TP. Inhibition of radiation induced lipid peroxidation by curcumin. Int J Pharm 1997; (151): 127-130. 
• Priyadarsini KI. Free radical reactions of curcumin in membrane models. Free Radic Biol Med 1997; 23(6): 838-843. 
• Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung 1996; 46(2): 169-171.
• Bharat B. Aggarwal, Annu Rev Nutr. Author manuscript; available in PMC 2011 Jul 26.  Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals, 2010 Aug 21; 30: 173–199.